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Different synaptic properties of GABAergic neurons integrated into the Olfactory Bulb during adulthood.

Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. The vast majority of adult-generated interneurons in the Olfactory Bulb become granule cells. Interestingly, there are several physiological differences between immature granular cells and those that have matured and are stably integrated within the circuit. In fact, previous… Sigue leyendo Different synaptic properties of GABAergic neurons integrated into the Olfactory Bulb during adulthood.

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Understanding sensory-motor circuits, the hierarchical level of the cerebral cortex.

In a recent study, Suter and Sheperd identify many shared features in the circuits of primary motor (M1) and secondary somatosensory (S2) cortices and show that these areas communicate via mutual projections that give each area monosynaptic access to the other one. These interareally corticoespinal (CSPs) neuron circuits may enable M1 and S2 to operate in… Sigue leyendo Understanding sensory-motor circuits, the hierarchical level of the cerebral cortex.

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The cancer therapeutic implications of the Warburg effect.

Whereas normal human cells use a process named mitochondrial oxidative phosphorylation (MOP) to generate energy from glucose, some unicellular organisms (eg: microbes) use a different process called anaerobic glycolysis to reproduce as quickly as possible when nutrients are available. The Nobel laureate, Otto Warburg, noticed in 1924 that cancer cells metabolize glucose in a different… Sigue leyendo The cancer therapeutic implications of the Warburg effect.

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Low carb diets. Useful as autoimmune disease treatment?

Inflammation is an immune physiological process that usually helps to control infections as well as in the subsequent repair of the affected tissue. Inflammasomes are multiproteic complexes expressed by the innate immune system cells whose activation induces the release of proinflammatory substances as interleukin-1. These multiproteic complexes are clinically-important because some autoimmune diseases express an… Sigue leyendo Low carb diets. Useful as autoimmune disease treatment?

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Can bacteria cause pain?

What is the cause of the pain produced during an infection? Until now it was thought that it is originated by the inflammatory response triggered by immune-derived substances such as cytokines, prostaglandins and growth factors. However, in a recent study published in Nature, researchers from Harvard University found that some peptides in bacteria can directly activate… Sigue leyendo Can bacteria cause pain?